TRT vs Clomid for Low Testosterone
Both treatments can help with low testosterone, but they work differently and may be better suited for different situations. Here's what you need to know.
Testosterone Replacement (TRT)
Best for men who want reliable results, aren't planning to conceive soon, or haven't responded to other treatments.
Clomid (Clomiphene)
Best for younger men who want to preserve fertility or try a non-injectable option first.
Detailed Comparison
| Factor | TRT | Clomid |
|---|---|---|
| How It Works | Directly replaces testosterone through injections, gels, or pellets | Stimulates your body to produce more testosterone naturally by blocking estrogen |
| Effectiveness | Highly effective - raises testosterone levels reliably and predictably | Variable - works for some men but results can be inconsistent |
| Fertility Impact | Can reduce sperm count and fertility (often reversible) | May preserve or improve fertility while raising testosterone |
| Time to Results | 2-4 weeks for initial improvements, 3-6 months for full benefits | 4-6 weeks, but may take longer for stable results |
| Administration | Injections (weekly/bi-weekly), daily gels, or pellets every 3-6 months | Oral medication taken daily or every other day |
| Monitoring Required | Regular blood tests for testosterone, hematocrit, PSA | Regular blood tests plus vision checks (rare side effect) |
| Common Side Effects | Acne, hair changes, testicular shrinkage, increased red blood cells | Mood changes, visual disturbances (rare), headaches |
| Cost (Monthly) | $80-150/month on average | $30-60/month on average |
Considerations & Drawbacks
TRT Considerations
Clomid Considerations
The Bottom Line
Choose TRT if: You want reliable, predictable results and aren't actively trying to conceive. TRT is the gold standard for testosterone replacement with decades of research behind it.
Consider Clomid if: You're younger, want to preserve fertility, or prefer to try an oral medication before committing to injections. It can be a good first-line option for some men.
The best choice depends on your specific situation, lab results, symptoms, and goals. Many men start with one and switch to the other based on results.
Not Sure Which is Right for You?
Our providers can review your symptoms and lab work to recommend the best approach for your specific situation. Schedule a free consultation today.