Tirzepatide vs Semaglutide
Both are GLP-1 medications that can help you lose significant weight. But they work slightly differently and may produce different results. Here's how they compare.
The Key Difference
Tirzepatide targets two hormones (GIP and GLP-1), while Semaglutide targets only one (GLP-1). This dual action may explain why Tirzepatide shows greater weight loss in head-to-head studies.
What the Research Shows
Tirzepatide Results
Average body weight lost at highest dose in SURMOUNT-1 trial
• 52% of patients lost ≥20% body weight
• Significant improvements in blood pressure
• Better HbA1c reduction for diabetics
Semaglutide Results
Average body weight lost in STEP 1 trial (2.4mg dose)
• 32% of patients lost ≥20% body weight
• Cardiovascular benefits documented
• Longer real-world safety data available
*Individual results vary. These are averages from clinical trials with specific patient populations.
Side-by-Side Comparison
| Factor | Tirzepatide | Semaglutide |
|---|---|---|
| Brand Names | Mounjaro, Zepbound | Ozempic, Wegovy, Rybelsus |
| Mechanism | Dual GIP and GLP-1 receptor agonist | GLP-1 receptor agonist only |
| Average Weight Loss | 15-22% of body weight in studies | 12-15% of body weight in studies |
| Administration | Weekly subcutaneous injection | Weekly injection (Ozempic/Wegovy) or daily oral (Rybelsus) |
| Starting Dose | 2.5 mg weekly | 0.25 mg weekly (injection) |
| Maximum Dose | 15 mg weekly | 2.4 mg weekly (for weight loss) |
| Time to Max Dose | 20+ weeks with gradual increases | 16-20 weeks with gradual increases |
| FDA Approval | 2022 (diabetes), 2023 (weight loss) | 2017 (diabetes), 2021 (weight loss) |
| Typical Monthly Cost | $400-600 (compounded) | $300-500 (compounded) |
Unique Benefits of Each
Why Choose Tirzepatide
Why Choose Semaglutide
Side Effects (Similar for Both)
Both medications have similar side effect profiles, mostly GI-related and typically improve over time.
Most side effects are dose-dependent and improve as your body adjusts. Starting low and increasing gradually helps minimize discomfort.
Our Recommendation
For maximum weight loss: Tirzepatide shows better results in clinical trials, with patients losing an average of 5-7% more body weight compared to semaglutide.
For proven track record: Semaglutide has been around longer with more real-world data and may be more accessible or affordable depending on your insurance.
Either can work: Both medications produce significant, life-changing weight loss for most patients. The "best" choice depends on your medical history, insurance coverage, and personal preferences.
Ready to Start Your Weight Loss Journey?
Our medical team can help you determine which medication is right for your body and goals. Schedule a free consultation to discuss your options.